Appeal No. 95-0865
Application 08/08/007,950
18. A nitroimidazole in its tetrabutylammonium salt
form is described at page 1312.
19. A reaction of nitroimidazole in its
tetrabutylammonium salt form with a benzyl halide (e.g., benzyl
chloride; first example in Table 1) proceeds generally along the
following lines (chemical reaction equation is not balanced):
Slusarchyk European Patent Application 0 352 013
20. Slusarchyk is similar to Bisacchi. As will become
apparent, however, there are some differences.
21. Slusarchyk describes the preparation of
Compound 15, which is a 2-amino-6-chloro-9-[3-monosubstituted]
purine having the formula (page 7, line 47 through page 8,
line 10):
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