Appeal No. 95-0865 Application 08/08/007,950 Level of ordinary skill in the art 37. The art involved in this case is the purine art, and more particularly, the reaction of purines with other compounds in such a manner that the other compound attaches to the 9-position of the purine. The prior art (Bisacchi, Slusarchyk, Hagberg I, Ichikawa and Zahler), with the exception of Searcey, is within the field of applicants' endeavor. 38. Searcey, while not dealing with purines, is relevant because it addresses a problem applicants sought and the prior art seeks to solve, viz., attaching moieties to the NH of an imidazole ring, it being noted that a purine includes an imidazole ring. 39. The hypothetical person having ordinary skill in the art would have been aware of the teachings of the prior art mentioned above. B. Discussion 1. The examiner's rejection based on Bisacchi, Slusarchyk and Searcey The examiner rejected claims 6-19 and 22 under 35 U.S.C. § 103 over Bisacchi, Slusarchyk and Searcey. All of these claims require the use of a protected disubstituted cyclobutane having a leaving group X which is one of: - 18 -Page: Previous 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 NextLast modified: November 3, 2007