Ex parte SINGH et al. - Page 18




          Appeal No. 95-0865                                                           
          Application 08/08/007,950                                                    

                          Level of ordinary skill in the art                           
                    37. The art involved in this case is the purine art,               
          and more particularly, the reaction of purines with other                    
          compounds in such a manner that the other compound attaches to               
          the 9-position of the purine.  The prior art (Bisacchi,                      
          Slusarchyk, Hagberg I, Ichikawa and Zahler), with the exception              
          of Searcey, is within the field of applicants' endeavor.                     
                    38. Searcey, while not dealing with purines, is                    
          relevant because it addresses a problem applicants sought and the            
          prior art seeks to solve, viz., attaching moieties to the NH of              
          an imidazole ring, it being noted that a purine includes an                  
          imidazole ring.                                                              
                    39. The hypothetical person having ordinary skill in               
          the art would have been aware of the teachings of the prior art              
          mentioned above.                                                             

               B.   Discussion                                                         

                    1.   The examiner's rejection based on                             
                         Bisacchi, Slusarchyk and Searcey                              
               The examiner rejected claims 6-19 and 22 under 35 U.S.C.                
          § 103 over Bisacchi, Slusarchyk and Searcey.  All of these claims            
          require the use of a protected disubstituted cyclobutane having a            
          leaving group X which is one of:                                             

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