Appeal No. 95-0865
Application 08/08/007,950
page 8, line 36 where R is described as being inter alia alkyl1
containing 1-8 carbon atoms, with methyl being 1 carbon].
35. Pertinent to the issues involved in this appeal is
the method described by Hagberg I in Example 10 (pages 33-34).
Example 10 describes a reaction of
a. 2-amino-6-benzyloxypurine in the form of a
tetrabutylammonium salt [Hagberg I Compound
7 11
XII where R is benzyloxy ()OCH C H ) and R
26 5
is hydrogen () H)]
b. with (S)-4-O-methanesulfonyl-1,2-O-
isopropylidenebutane-1,2,4-triol [Hagberg I
Compound XIII (left side) where X is2
methanesulfonyloxy [i.e., mesyl] and R and1
R are methyl].12
The significant teaching of Example 10 is that a purine in its
tetraalkylammonium salt form may be reacted with a compound
having a mesyl leaving group. Searcey, on the other hand,
describes only the use of halo leaving groups on the compounds
reacted with the imidazole in its tetraalkylammonium salt form.
36. Findings with respect to other prior art, e.g.,
Ichikawa and Zahler, can be found in the Discussion portion of
this opinion.
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