Appeal No. 95-0865
Application 08/08/007,950
14. Bisacchi lists four possibilities for W (col. 4,
lines 31-37 and col. 7, last line through col. 8, first line).
15. The process described by Bisacchi differs from
applicants' claim 6 in that Bisacchi describes the use of purines
in potassium or sodium salt form whereas applicants claim the use
of a purine in its tetraalkylammonium salt form.
Searcey
16. Searcey describes the reaction of a nitroimidazole
with an "appropriate halo compound" (page 1309, first paragraph)
to make substituted nitroimidazole compounds. In order to
overcome certain yield problems said to occur using then known
methods (page 1309, beginning with second full paragraph through
page 1310, line 13), Searcey describes an investigation of the
reaction of a nitroimidazole compound in the form of a
tetraalkylammonium salt with the halo compound (page 1310, lines
13-17).
17. Table 1 (page 1311) of Searcey describes, better
yields when the halo compound is reacted with the nitroimidazole
compound in the form of a tetraalkylammonium salt vis-à-vis the
same nitroimidazole compound in the form of an alkali salt, e.g.,
a sodium salt.
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