Ex parte SINGH et al. - Page 36




          Appeal No. 95-0865                                                           
          Application 08/08/007,950                                                    

               The addition of steps (b) and (c) to what is otherwise                  
          basically the process of Claim 6 does not render Claim 13, as a              
          whole, patentable over the prior art.  A person having ordinary              
          skill in the art would have wanted the oxo compound because it is            
          a known active and useful compound (specification, page 1;                   
          Bisacchi, col. 1, lines 7-20).  Steps (b) and (c), as shown by               
          the prior art, are conventional organic synthesis techniques.                

                         k.   Claim 14                                                 
               Claim 14 is rejected as being unpatentable over Bisacchi,               
          Slusarchyk, Searcey, Hagberg I, Ichikawa and Zahler.                         
               Claim 14 is believed to be unpatentable for the same                    
          reasons that Claim 13 is unpatentable.                                       
              Claim 14 requires that step (b) take place in the presence              
          of a fluoride ion.  Bisacchi describes the use of compounds which            
          produce fluoride ions to accomplish deprotection (col. 8,                    
          lines 29-31 and 53-54; col. 9, line 47).                                     
               Step (c) of Claim 14 further requires acid hydrolysis.                  
          Slusarchyk describes the use of aqueous hydrochloric acid to                 
          accomplish conversion of the chloro group to an oxo group (page              
          8, line 28).                                                                 




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