Appeal No. 95-0865
Application 08/08/007,950
(2) treating the product of part (a) with an acid such
as hydrochloric acid followed by sodium or
potassium hydroxide and heat (sic--heating)
to remove the protecting groups and convert the Y1
substituent to a 6-oxo ***.
Slusarchyk describes treatment of a product similar to that
obtained in applicants' step (a) with hot aqueous hydrochloric
acid to convert a chloro group in the 6-position to a 6-oxo group
(page 8, lines 28-48).
Bisacchi describes treatment of a compound like the compound
obtained in applicants' step (a) with potassium hydroxide to
remove the R protecting groups, particularly when the R group4 4
is an acyl group (col. 8, lines 44-50).
Step (c) requires separating the desired product from the
reaction mixture. Bisacchi describes obtaining a purified
product through chromatography (col. 9, lines 21-22).
Applicants' steps (b) and (c) would appear to involve
conventional techniques for removing protecting groups and
converting a chloro group in the 6-position to a 6-oxo group and
separating to obtain a desired product.
s. Claim 22--indefiniteness rejection
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