Ex parte SINGH et al. - Page 37




          Appeal No. 95-0865                                                           
          Application 08/08/007,950                                                    

               Applicants' claimed steps (b) and (c) would appear to                   
          involve use of well known organic synthesis techniques for their             
          intended purpose.                                                            

                         l.   Claim 15                                                 
               Claim 15 is rejected as being unpatentable over Bisacchi,               
          Slusarchyk, Searcey, Hagberg I, Ichikawa and Zahler.  Claim 15               
          is believed to be unpatentable for the same reasons that Claims              
          13-14 are unpatentable.  Claim 15 requires a "Prot" group which              
          is benzyl and use of boron trichloride to accomplish                         
          deprotection.  Bisacchi describes the use of R  protection groups4                             
          which are benzyl and their deprotection using, inter alia, boron             
          trichloride (col. 8, lines 35-44).                                           

                         m.   Claim 16                                                 
               Claim 16 is rejected as being unpatentable over Bisacchi,               
          Slusarchyk, Searcey, Hagberg I, Ichikawa and Zahler.                         
               Claim 16 is believed to be unpatentable for the same                    
          reasons that Claims 13-15 are unpatentable.  Claim 16 requires a             
          "Prot" group which is acetyl and use of sodium methoxide in                  
          methanol to accomplish deprotection.  Bisacchi describes the use             
          of R  protection groups which are acetyl and their deprotection4                                                                        
          using, inter alia, sodium methoxide in methanol (col. 8, lines               
          44-50).                                                                      
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