Appeal No. 95-0865
Application 08/08/007,950
Bisacchi contains an extensive discussion of the manner in which
protective groups are removed (col. 8, line 17 through col. 10,
line 14).
Step (c) involves treatment of the deprotected compound to
convert the Y group from a chloro ()Cl) to an oxo group to
1
produce the compound [1R-(1",2$,3")]-2-amino-9-[2,3-
bis(hydroxymethyl)-cyclobutyl]-1,9-dihydro-6H-purin-6-one
according to the following reaction scheme:
Slusarchyk describes the conversion of a chloro-compound to an
oxo-compound (page 8, lines 28-48).
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