Appeal No. 94-4009 Paper No. 32
Application No. 07/953,716 Page 2
assignee of record for the following three related patents for
pharmaceutical compositions known as mevalonolactones:
Fujikawa et al., 5,011,930, issued 30 Apr. 1991 ('930);
Fujikawa et al., 5,024,999, issued 18 June 1991 ('999);
and
Fujikawa et al., 5,026,698, issued 25 June 1991 ('698).
Appellants state, and the prior art teaches, that "the
compounds of Fujikawa et al[.]...are useful as curing agents
against hyperlipidemia, hyperlipoproteinemia and
atherosclerosis" (Paper No. 18 (App. Br.) at 7 (emphasis in
original, citations omitted); '930 at 12:8-11; '999 at 26:31-
34; '698 at 28:11-14).
The subject matter claimed in the present application is
best illustrated in the sole independent claim, claim 11,
which begins (Paper No. 8 (22 June 1993 Admt.) at 1-2):
A method for inhibiting proliferation of aortic
intimal smooth muscle cells, inhibiting migration of
aortic medial smooth muscle cells into intima, or
inhibiting adhesion of blood cells to endothelium,
comprising administering to a patient in need
thereof prior to atherosclerotic intimal thickening
an effective amount of a compound of the formula
(I):
[Formula omitted].
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