Appeal No. 94-4009 Paper No. 32 Application No. 07/953,716 Page 2 assignee of record for the following three related patents for pharmaceutical compositions known as mevalonolactones: Fujikawa et al., 5,011,930, issued 30 Apr. 1991 ('930); Fujikawa et al., 5,024,999, issued 18 June 1991 ('999); and Fujikawa et al., 5,026,698, issued 25 June 1991 ('698). Appellants state, and the prior art teaches, that "the compounds of Fujikawa et al[.]...are useful as curing agents against hyperlipidemia, hyperlipoproteinemia and atherosclerosis" (Paper No. 18 (App. Br.) at 7 (emphasis in original, citations omitted); '930 at 12:8-11; '999 at 26:31- 34; '698 at 28:11-14). The subject matter claimed in the present application is best illustrated in the sole independent claim, claim 11, which begins (Paper No. 8 (22 June 1993 Admt.) at 1-2): A method for inhibiting proliferation of aortic intimal smooth muscle cells, inhibiting migration of aortic medial smooth muscle cells into intima, or inhibiting adhesion of blood cells to endothelium, comprising administering to a patient in need thereof prior to atherosclerotic intimal thickening an effective amount of a compound of the formula (I): [Formula omitted].Page: Previous 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 NextLast modified: November 3, 2007