Ex parte SAITO et al. - Page 6




          Appeal No. 94-4009                                   Paper No. 32           
          Application No. 07/953,716                                 Page 6           
          that the compounds may be used to inhibit after intimal                     
          thickening or even lesions have occurred:                                   
                    Accordingly, as a more effective inhibitor on                     
               atherosclerotic intimal thickening, a drug capable                     
               of directly acting on such atherosclerotic lesion,                     
               is desired. [Paper No. 1 (Spec.) at 2 (emphasis                        
               added).]                                                               
                    The compound of the present invention may be [a]                  
               potent inhibitor [of] adhesion of blood cells (such                    
               as monocytes, macrophages), to endothelial cells,                      
               and may [] suppress the response of [the] early                        
               phase for atherosclerotic thickening.  [Paper No. 1                    
               (Spec.) at 6 (emphasis added).]                                        
               Since Appellants use the same compounds in the same                    
          dosages as Fujikawa, patients treated according to Fujikawa's               
          teachings would be expected to obtain the same benefits.                    
          Thus, these purposes do not--by themselves--distinguish the                 
          claimed subject matter from Fujikawa's methods.  In re Spada,               
          911 F.2d 705, 708,  15 USPQ2d 1655, 1657 (Fed. Cir. 1990) (A                
          new use will not make an old compound patentable).  The                     
          question remains, however, whether having one of these                      
          purposes further limits the steps of the method.                            
               Administering to a patient in need thereof                             
               The question this phrase of claim 11 presents is what is               
          it that the patient is in need of?  Grammatically, the                      
          "thereof" refers to an effective amount of the compounds to be              
          administered.  Cf. In re Hyatt, 708 F.2d 712, 714, 218 USPQ                 






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