Appeal No. 95-2613
Application 07/876,794
the subject matter on appeal and read as follows:
1. An improved method for recombinant production of a
human gonadotropin, which method comprises culturing animal
cells that contain regulated secretory granules and which
cells have been transformed with an expression system capable
of expressing a DNA encoding said gonadotropin under
conditions wherein said encoding DNA is expressed, and
recovering the gonadotropin from the culture medium.
2. The method of claim 1 wherein said cells are
pituitary cells.
3. The method of claim 2 wherein said pituitary cells
are GH cells.
3
7. A cell culture capable of secreting a human
gonadotropin which cell culture comprises animal cells that
contain regulated secretory granules and which cells have been
transformed with an expression system capable of expressing a
DNA encoding said gonadotropin under conditions wherein said
encoding DNA is expressed, and
recovering the gonadotropin from the culture medium.
8. The culture of claim 7 wherein said cells are
pituitary cells.
9. The culture of claim 8 wherein said pituitary cells
are GH cells.
3
The references relied on by the examiner are:
Boime WO 90/09800 Sept. 7, 1990
(PCT Application)
Vander et al. (Vander), Human Physiology, The Mechanisms of
Body Function, Second Edition, McGraw-Hill, Inc., NY, p. 184
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