Appeal No. 95-2613
Application 07/876,794
containing animal cells which have been transformed with an
expression vector which is capable of expressing a DNA
sequence encoding a human gonadotropin. The specification
states that
Certain cells are known to contain dense-
core secretory granules and to secrete proteins
through a regulated pathway, which can be
stimulated by certain substances, for example,
forskolin. These cells or cell lines, derived
from appropriate animal tissues, are the host
cells of the invention. Included among such
cells are cells of the secretory components of
the hormone system such as the pituitary, $
islet cells, and cells of the adrenal cortex.
Particularly preferred in the method of the
invention are pituitary-derived cells.
Consistent with the foregoing paragraph,
“cells derived from pituitary” refers [to] the
cells or cell lines which are cultured from
pituitary tissue derived from animal species, in
particular mammalian species, and more
particularly, human or murine pituitaries.
Illustrated herein is the GH murine cell line
3
... [Specification, p. 7, line 30- p. 8, line
9].
The results obtained by transforming the rat pituitary
cell line GH with expression vectors encoding the $ subunits
3
of LH, CG or FSH and the common " subunits are set forth on
pp. 14-16 of the specification and in Figure 3.
Although only two of the eight claims on appeal are
4
Page: Previous 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 Next
Last modified: November 3, 2007