Appeal No. 95-2613
Application 07/876,794
(1975).
Hellerman et al. (Hellerman), “Secretion of human parathyroid
hormone from rat pituitary cells infected with a recombinant
retrovirus encoding preproparathyroid hormone”, Proc. Natl.
Acad. Sci. USA, Vol. 81, pp. 5340-5344 (Sept. 1984).
Clayton, et al. (Clayton), “Expression of luteinising hormone-
$
subunit chloramphenicol acetyltransferase (LH-$-CAT) fusion
gene in rat pituitary cells: induction by cyclic 3'-adenosine
monophosphate (cAMP)”, Molecular and Cellular Endocrinology,
Vol. 80, pp. 193-202 (1991).
Claims 1 through 4 and 7 through 10 stand rejected under
35 U.S.C. § 103 as being unpatentable over Boime in view of
either Hellerman or Clayton, and Vander.
We reverse.
Background
Human reproductive hormones (gonadotropins) are a family
of “heterodimeric glycoprotein hormones which have a common "
subunit, but [which] differ in their hormone-specific $
subunits.” Specification, p. 1, lines 18-21. The claimed
invention is directed to a method of producing human
gonadotropins by culturing regulated secretory granule-2
2Human gonadotropins are reproductive hormones which include follicle-
stimulating hormone (FSH), luteinizing hormone (LH), thyrotropin or thyroid-
stimulating hormone (TSH) and human chorionic gonadotropin (CG).
3
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