Appeal No. 95-2710
Application 08/011,837
least one pan semen antibody capable of binding, directly or
indirectly, to cells and pathogens in semen, thereby trapping
said cells and pathogens in semen, including sexually
transmitted disease pathogens and cells infected with sexually
transmitted disease pathogens, in mucus secretions present in
said vaginal cavity or uterus;
by means of a biologically compatible prolonged released
carrier therefor,
wherein said at least one pan semen antibody is contacted
with and binds, directly or indirectly, to said cells and
pathogens in semen and thereby effects said trapping.
58. A method of passively immunizing skin surfaces and
mucus epithelial surfaces comprising applying to said surfaces
a pharmaceutical composition comprising
at least one pan semen antibody capable of binding,
directly or indirectly, to viruses and cells in semen, thereby
trapping said cells and viruses in mucus secretions present on
said skin or mucus epithelial surfaces, wherein said antibody
is present in an amount sufficient to effect said trapping,
and
a pharmaceutically acceptable carrier,
under conditions such that said trapping is effected.
THE REFERENCE
Shinzo Isojima et al. (Isojima), “Establishment and
characterization of a human hybridoma secreting monoclonal
antibody with high titers of sperm immobilizing and
agglutinating activities against human seminal plasma”, 10 J.
Reprod. Immunology 67-78 (1987).
THE REJECTIONS
The claims stand rejected as follows: claims 52, 54, 55
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