Ex parte CONE et al. - Page 9




             Appeal No. 95-2710                                                                                   
             Application 08/011,837                                                                               


             art to bind sperm cells in semen, but have not admitted that                                         
             pan semen antibodies were known which bind to and trap all                                           
             cells and pathogens in semen (brief, page 11).  Appellants’                                          
             argument is not well taken in view of the fact that the                                              
             antibodies used by appellants were known by and obtained from                                        
             others (specification, page 12, lines 14-36).  Appellants also                                       
             argue that they have not admitted that methods were known to                                         
             apply a pan semen antibody into the vaginal cavity or uterus                                         
             or to skin surfaces or mucus epithelial surfaces (brief, page                                        
             11).                                                                                                 
                    The examiner argues that Isojima teaches that H6-3C4,                                         
             which is one of the antibodies recited in appellants’ claims                                         
             59-61, was known in the art to immobilize sperm and cause                                            
             contraception, and that agglutination of pathogenic cells                                            
             would be inherent with the administration of the antibody                                            
             (answer, page 4).  Appellants argue that Isojima does not                                            
             disclose an antibody that binds to cells other than sperm                                            
             cells or to pathogens in semen (brief, page 12).  Appellants’                                        
             argument is not persuasive because Isojima discloses H6-3C4                                          
             (page 67) which, appellants state (specification, page 17,                                           
             lines 30-33), agglutinates virtually all cells present in                                            
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