Ex parte CONE et al. - Page 10




             Appeal No. 95-2710                                                                                   
             Application 08/011,837                                                                               


             semen.  Appellants also argue that Isojima does not disclose                                         
             application of a pan semen antibody into the vaginal cavity or                                       
             uterus or to the skin surfaces and mucus epithelial surfaces                                         
             (brief, page 13).                                                                                    
                    In order for a claimed invention to be anticipated under                                      
             35 U.S.C. § 102(b), all of the elements of the claim must be                                         
             found in one reference.  See Scripps Clinic & Research Found.                                        
             v. Genentech Inc., 927 F.2d 1565, 1576, 18 USPQ2d 1001, 1010                                         
             (Fed. Cir. 1991).  The examiner has the initial burden of                                            
             establishing a prima facie case of anticipation by pointing                                          
             out where all of the claim limitations appear in a single                                            
             reference.  See In re Spada, 911 F.2d 705, 708, 15 USPQ2d                                            
             1655, 1657 (Fed. Cir. 1990); In re King, 801 F.2d 1324, 1327,                                        
             231 USPQ 136, 138-39 (Fed. Cir. 1986).                                                               
                    Each of appellants’ claims requires a step of applying                                        
             the at least one pan semen antibody, either into the vaginal                                         
             cavity or uterus of a female mammal or to the skin surfaces                                          
             and mucus epithelial surfaces.  Appellants do not acknowledge                                        
             that this step was known in the art.  Also, the examiner does                                        
             not point out, and we do not find, where Isojima describes                                           


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