Appeal No. 95-3606
Application 07/827,691
a) at least one oligonucleotide primer capable
of hybridizing to nucleic acid sequences from an
individual, wherein said sequences are selected from
the group of sequences that consists of (I)
sequences
that are present within the FMR-1 fragile site, and
(ii) sequences that are sufficiently near the FMR-1
GC-rich fragile site to yield a PCR product;
b) nucleotide analogue selected from the group
consisting of 7-deaza GTP, inosine, and 7-deaza
inosine; and
c) a PCR reaction mixture which is
substantially
free of added GTP or dGTP.
Discussion
1. Claim interpretation
Preliminarily, we note the following statement in the
examiner’s Second Supplemental Examiner’s Answer (Sec. Suppl.
Ans.), mailed August 23, 1995, page 3, second full paragraph,
which reads:
While Kremer does not explicitly teach combining
the materials of the method together in a kit, it would
have been prima facie obvious to one of ordinary skill
in the art at the time the invention was made to package
the materials together in the manner convenient for use
to one of ordinary skill in the art.
In so stating, the examiner apparently concludes that the
materials employed to perform the methods of Claims 41, 10,
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