Ex parte PERGOLIZZI et al. - Page 6




          Appeal No. 95-3606                                                          
          Application 07/827,691                                                      
               is performed in a reaction mixture that is substantially               
               free of both GTP and dGTP.                                             
               Next, the nucleotide analogues of method Claim 41 and kit              
          Claim 42 are “selected from the group consisting of 7-deaza                 
          GTP, inosine, and 7-deaza inosine.”  However, consistent with               
          the teaching in the specification, we hold that the term “7-                
          deaza GTP” in Claims 41 and 42 reads on both 7-deaza GTP and                
          7-deaza dGTP.   See the Specification (Spec., p. 19, l. 4-11;2                                                              
          emphasis added):                                                            
                    The process of the present invention uses an                      
               analogue of guanosine nucleotide.  U.S. Patent                         
               No. 4,804,748 discloses analogues useful in the                        
               present invention and is hereby incorporated by                        
               reference.  Preferred analogues include inosine,                       
               7-deaza-guanosine and 7-deaza inosine nucleotides                      
               (both ribo- and deoxyribo-).  The 2'-deoxy analogues                   
               are more preferred and the 7-deaza-2'deoxy guanosine                   
               (7-deaza-2'-dGTP) analogue is further preferred.                       
               Finally, we hold that the functional language, “for                    
          ascertaining whether an individual is a carrier for, or                     
          afflicted with Fragile X” in Claim 41, considered in                        
          conjunction with the “reaction mixture that is substantially                
          free of GTP and dGTP” and in light of the supporting                        


            A patent applicant may be his own lexicographer so long as2                                                                      
          he sets out his definition in the specification.  Intellicall,              
          Inc. v. Phonometrics, Inc., 952 F.2d 1384, 1387-88, 21 USPQ2d               
          1383, 1386 (Fed. Cir. 1992).                                                
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