Ex parte PERGOLIZZI et al. - Page 9




          Appeal No. 95-3606                                                          
          Application 07/827,691                                                      
               Claim language is to be given the broadest reasonable                  
          interpretation which is consistent with the invention                       
          described in the specification.  In re Zletz, 893 F.2d 319,                 
          321, 13 USPQ2d 1320, 1322 (Fed. Cir. 1989).  The specification              
          here clearly states that PCR reaction mixtures which are not                
          substantially free of dGTP cannot reliably detect the fully                 
          mutated fragile X gene.  In the kit of Claim 42, the PCR                    
          reaction mixtures need not be substantially free of dGTP.3                  
          Accordingly, we hold that the examiner erred in concluding                  
          that “Claim 42 is drawn to a kit having the reagents recited                
          in the method of claim 41" (Sec. Suppl. Ans., p. 2, third                   
          para., last sentence).                                                      
          2.   Prior art teaching                                                     
               A.   Kremer                                                            
               The examiner characterizes Kremer’s disclosure and                     
          teachings as follows (Sec. Suppl. Ans., p. 3):                              
                    Kremer teaches, in Figure 1B, amplification of a                  
               region of the FMR-1 gene, “PCR products spanning the                   
               p(CCG)n repeat [a GC rich region] were generated.”                     
          Kremer                                                                      
               also teaches using primers from the FMR-1 GC-rich fragile              

              3    In light of the teaching in the specification and the             
          scope of method Claim 41, we surmise that applicants intended to            
          limit the PCR reaction mixture in the kit of Claim 42 to a                  
          reaction mixture which is substantially free of GTP and dGTP.               
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