Appeal No. 1997-0472 Application No. 08/259,152 However, as noted by the examiner, the reason that D'H forms an aqueous solution of a plasminogen activator and an anionic polymer is not germane to the patentability of the claimed composition. We note that one of the present inventors, Yukio Shimazaki, filed a declaration under Rule 132 on June 13, 1994. However, since appellants' brief makes no reference to the declaration and bases no argument thereon, we have assigned no probative value to the Declaration in reaching our conclusion of obviousness for the claimed subject matter. One final point remains. Since we find that D'H discloses an aqueous solution comprising appellants' t-PA and anionic polymer, we invite the examiner to reconsider the allowability of claim 31 which is drawn to a method of increasing the solubility of t-PA in aqueous solution by adding an anionic polymer to the solution. It would seem that D'H describes or, at least, renders obvious the claimed method of adding an anionic polymer to an aqueous solution of t-PA, 6Page: Previous 1 2 3 4 5 6 7 8 9 NextLast modified: November 3, 2007