BRAKE v. SINGH - Page 76




               Interference 102,728                                                                                                  
               inventor.  That is, an inventor could always have been doing something else, but                                      
               instead, performed Experiment X, ordered reagent Y, etc.  If we were to apply this                                    
               method of reasoning, it would mean that whenever any work of an inventor is offered                                   
               that it should be accepted as evidence of conception, diligence, etc., because the                                    
               inventor could have been doing something else.  It would be impossible to determine                                   
               priority, or resolve other issues, if each time we considered what the inventors could                                
               have otherwise have been doing, as opposed to what they did do?  In our view, our                                     
               fact-finding duty is best discharged when we consider what an inventor has done, and                                  
               based on the evidence provided, determine whether a party has met its burden of proof                                 
               for the issue at hand.                                                                                                
                       To that end, when we consider the 24-mer itself, and not what oligonucleotides                                
               could have been ordered, we agree with Brake, that if Dr. Singh wanted an                                             
               oligonucleotide which was complementary to the “sequence at the junction” (SX 3,                                      
               Bates No. 108), for any purpose, he had a choice of only one oligonucleotide due to                                   
               natural base-pairing laws.  Paper No. 190, p. 66.  We are not aware of any other                                      
               possibilities.                                                                                                        
                       As to Singh’s reliance on the testimony of Dr. Singh (SR 564, para. 47), Mr. Ng                               
               (SR 478, para. 11), and Mr. Vasser (SR 1059, para. 4), to support its position with                                   
               respect to the possible number of oligonucleotides Dr. Singh could have ordered, we                                   
               direct attention to our discussions of these declarations above.  Contrary to Singh’s                                 
               argument, we find no mention of the mathematical calculation, or of the 24-mer being                                  
               one of 2.8 x 1014 possible 24-mers that Dr. Singh could have ordered.  Thus, on the                                   

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