BRAKE v. SINGH - Page 80




               Interference 102,728                                                                                                  
               of objective evidence, we accord arguments of counsel little, or no, evidentiary weight.                              
               In re Payne, 606 F.2d at 315, 206 USPQ at 256; Meitzner v. Mindick, 549 F.2d at 782,                                  
               193 USPQ at 22; In re Lindner, 457 F.2d at 508, 173 USPQ at 358.                                                      
                       We are mindful of the Court’s concern that the no other “substantial use” rule set                            
               forth in Berges v. Gottstein, 618 F.2d 771, 774-75, 205 USPQ 691, 694 (CCPA 1980),                                    
               may be applicable to the facts of this case.  Singh v. Brake, 222 F.3d at 1369, 55                                    
               USPQ2d at 1678.  However, we agree with Brake that there are many facts which                                         
               distinguish the present case from Berges and thus preclude Singh from coming within                                   
               Berges.                                                                                                               
                       First, the issue in Berges, was whether the inventor’s own evidence of an actual                              
               reduction to practice of a compound within the scope of the count was adequately                                      
               corroborated.  Berges v. Gottstein, 618 F.2d at  772, 205 USPQ at 692.                                                
                       Here, the issue is conception and whether the inventor’s own evidence                                         
               adequately corroborates completion of the mental part of the invention.  Burroughs                                    
               Wellcome Co. v. Barr Laboratories, Inc., 40 F.3d at 1228, 32 USPQ2d at 1919.  That is,                                
               whether Dr. Singh’s notebooks and an order for one of two unique reagents needed to                                   
               perform a novel method are sufficient to establish conception of (i) a compound within                                
               the scope of the count, and (ii) an operative method of making it.  Burroughs Wellcome                                
               Co. v. Barr Laboratories, Inc., 40 F.3d at 1229-30, 32 USPQ2d at 1921; Fiers v. Revel,                                


               interferon molecule containing the natural N-terminus.”  Application No. 06/506,098,                                  
               p. 26, lines 3-6.  We find no mention of loop deletion mutagenesis or the use of the                                  
               LAC primer in Singh’s application.  We note that Singh does argue conception plus                                     
               diligence of the method relied upon to establish constructive reduction to practice.                                  
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