Interference 103,579
segment (~1200 bp),
(ii) a 5'-3' PGBSS coding region including a major
fraction of the 1000-2000 bp segment, the entire 2000-3000 bp
segment, the entire 3000-4000 bp segment, and a minor fraction of
the 4000-4964 bp segment (~3000 bp); and
(iii) a terminator region including a major fraction of
the 4000-4964 bp segment (~750 bp).
V. Leij (VDX 3) describes the “complete genomic nucleotide
sequence” of the PGBSS gene, excluding the putative promoter
sequences and polyadenylation signals (VDX 3, Fig. 1, p. 243), as
having 2961 bp (~3000 bp)(VDX 3, Fig. 1, p. 243). Leij’s 2961 bp
5'-3' genomic DNA sequence is the 5'-3' gDNA sequence indicated
by the bold arrow above the 0-4964 bp PCT SEQ ID No. 5 in
VDX 15/HDX 8.
VI. The 5'-3' genomic DNA sequence depicted by the
antisense arrow at the top of Kuipers’ Fig. 1A (VDX 4, p. 748/
HR 339) is defined as follows (VDX 4, p. 748, Fig. 1A,B/HR 339,
Fig. 1A,B; emphasis added):
The arrow on top indicates the gene including the
promoter region (5' dashed line) and the terminator
region (3' dashed line).
We find that the arrow on top of Kuipers’ Fig. 1A, including the
dashed line promoter and dashed line terminator regions,
corresponds to, or at least approximates, Hofvander’s 4964 bp
-69-
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Last modified: November 3, 2007