Ex Parte MCGREGOR et al - Page 7




              Appeal No. 2002-0450                                                                                     
              Application No. 09/142,814                                                                               
              methods of Silver are substantially similar to the instant methods of preparing a wound                  
              dressing material.   Id.                                                                                 
                     The examiner summarizes:                                                                          
                     Although Berg does not fully teach the incorporation of second                                    
                     biodegradable polymers such as polylactic acid, polyglycolic acid                                 
                     copolymers in their composition, both Silver and Arnold respectively                              
                     indicate the use of second polymer in their compositions as means to                              
                     control releasing rate of the porous beads, or improving the                                      
                     biodegradation of their matrix system; therefore, it would have been                              
                     obvious to one ordinary skilled in the art at the time of invention to add the                    
                     second, non-porous biodegradable polymer, as taught by Silver or Arnold,                          
                     to Berg=s composition in the form of a coating to improve the duration of                         
                     activity, release rate or the biodegradation of such wound dressing                               
                     material when place in a wound site.   Id.                                                        

              We, again disagree with the examiner=s characterization of the diffusion control layer                   
              described by Silver and the matrix layer of Arnold.  The disclosure of Silver particularly               
              concerns a collagen sponge or sheet material.  Column 3, lines 34-43.  According to                      
              Silver, column 6, lines 45-64, each side of the collagen based matrix may be coated                      
              with a diffusion control layer which may be a biodegradable layer of polylactic acid or                  
              polyglycolic acid.                                                                                       
                     Appellants argue that the only form of collagen based matrix described in Silver                  
              is in the form of a sheet and not beads.  Brief, page 8.  Appellants argue that Arnold                   
              only discloses microsphere supported in a porous matrix and Silver only discloses                        
              sheets of matrix material.  Id.  The Appellants conclude that the only suggestion to do                  




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