Ex Parte Birkmayer - Page 5




          Appeal No. 2003-1804                                                        
          Application No. 09/896,209                                                  
          NADPH are administered to a person suffering from the syndrome or           
          its symptoms.”  (Birkmayer I, abstract).                                    
               Although Birkmayer I is directed to a method of treating               
          Chronic Fatigue Syndrome (CFS), persons with CFS show similar               
          symptoms to persons with jet lag or sleep deprivation.                      
          Birkmayer I teaches that “in patients suffering from Chronic                
          Fatigue Syndrome, a clear alleviation of their symptoms,                    
          including but not limited to fatigue, headaches, depression and             
          muscle pain and weakness, is achieved.”  (Birkmayer I, column 2,            
          lines 43-48).  Additionally, in Example II of Birkmayer I, a                
          patient “showed symptoms of fatigue for at least 6 months, sore             
          throat, painful lymph nodes, muscle weakness, muscle pains,                 
          headache, short term memory problems, forgetfulness and inability           
          to concentrate.”  (Birkmayer I, column 7, lines 38-41).  After              
          being treated with NADH, the “patient’s symptoms were                       
          alleviated.”  (Birkmayer I, column 7, lines 46-48).  “The patient           
          reported an improvement in the energy level as reflected by                 
          increased exercise programs and shorter lasting fatigue after               
          exercise.”  (Birkmayer I, column 7, lines 48-50).  Thus, symptoms           
          of Chronic Fatigue Syndrome are also common to jet lag and sleep            
          deprivation.  Accordingly, it would have been obvious to a person           
          having ordinary skill in the art at the time the invention was              
          made that a prior art method for treating symptoms of Chronic               

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