Appeal No. 2003-1804
Application No. 09/896,209
to get through the long hours that I keep to get
through my training.... From the first day that I took
ENADA, I noticed a difference immediately. I all of the
sudden had mental clarity with a sharp state of mind, was
able to think clearly, and felt more energetic....My muscles
seem to have an endless supply of energy to keep going
(I would get very fatigued very quickly before).
Birkmayer II teaches that NADH helps a person wake up, think
clearly, and have more energy. Decreased attentiveness,
decreased ability to concentrate, and decreased reaction time are
common symptoms of sleep deprivation and jet lag. One of
ordinary skill in the art at the time the invention was made
would have understood from Birkmayer II that administering NADH
likely would have been useful for alleviating symptoms of jet
lag, alleviating symptoms of sleep deprivation, and enhancing
attentiveness or reaction time.
Langsjoen and Bioactive Nutrients teach the use of coenzyme
Q10, L-Cartinine or L-glutathion to treat symptoms associated
with sleep deprivation, treat symptoms associated with jet lag,
or improve attentiveness or reaction time. Langsjoen teaches
that Q10 is used to alleviate symptoms of AIDS, such as fatigue
and malaise. (Langsjoen, column 3, lines 1-3). Bioactive
Nutrients teaches that a deficiency of Cartinine can cause
fatigue, muscle weakness, and brain degeneration. (Bioactive
Nutrients).
-7–
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