Interference 103,781
Adang argues (AB 45):
By 1985, . . . Drs. Adang and Murray recognized
that . . . [tobacco plants transformed to express
insecticidal amounts of Bt toxin protein] exhibited
very low levels of Bt RNA. Dr. Adang and Dr. Murray
discussed this Bt expression problem and proposed
modifying the Bt DNA sequence in order to increase
expression of Bt toxin genes in plants. On or about
November 6, 1985, Dr. Adang and Dr. Murray memorialized
their conception of a method for designing a synthetic
insecticidal Bt gene by modifying a portion of the gene
to have a greater number of plant preferred codons
(See, e.g., Facts 29, 33-39).
Dr. Adang and Dr. Murray provided credible testimony
establishing a clear and permanent idea of the subject
matter defined by Adang claim 1. . . . .
(ii) The evidence
We move directly to “[t]he draft abstract (AX-106E) dated
November 6, 1985, that Adang initially planned to disclose at a
scientific meeting [which] . . . reflects Dr. Adang’s and Dr.
Murray’s concept to modify Bt genes to address premature
termination of transcription during the expression of Bt genes”
(AB 47, third full para.). The draft abstract (AX 106E) is, in
its entirety, reproduced below (emphasis added):
ucla2
M
ucla2
Abstract for UCLA symposium
NOVEL APPLICATION OF A BACILLUS THURINGIENSIS CRYSTAL
PROTEIN FOR INSECT CONTROL
-91-
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