Ex Parte Murphy et al - Page 16



               Appeal 2007-1378                                                                          
               Application 10/327,459                                                                    
           1   rejection.  What appellants’ argument amounts to is a “divide and conquer”                
           2   approach—since Singer does not show it all, then the combination of Singer                
           3   and Curatolo is “no good”.  Sometime ago, however, binding precedent                      
           4   made clear that an obviousness rejection cannot be overcome by attacking                  
           5   references individually—which is precisely what appellants are doing.  In re              
           6   Young, 403 F.2d 754, 757, 159 USPQ 725, 728 (CCPA 1968).                                  
           7         Appellants go on to say that Singer does not describe any                           
           8   azithromycin having a Carr’s Compression Index of less that 34%.  Appeal                  
           9   Brief, page 16.  Appellants are correct that there is no explicit description of          
         10    Carr’s Compression Index in Singer.  However, making a tablet is described                
         11    by Singer and any one skilled in the art would know from Curatolo precisely               
         12    how to make the tablet.  Not only that, but based on Curatolo, any one                    
         13    skilled in the art would know that through process choices, properties—                   
         14    including density—can be controlled.  On this record, for all we know,                    
         15    anyone successfully making a tablet using Singer’s azithromycin via the                   
         16    Curatolo dry granulation or direct compression process would get results                  
         17    similar to those of appellants.  Even if not so, one skilled in the art making a          
         18    granule to make the Singer tablet would obtain a granule having a Carr’s                  
         19    Compression Index of some value.  On this record we have no idea what that                
         20    Index number might be.                                                                    
         21          Appellants, of course, maintain that the Carr’s Compression Index of                
         22    less that 34% is unexpected.  We have already addressed why appellants’                   
         23    proofs fall short of those required by law to establish the “unexpected”                  
         24    nature of the results.                                                                    


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