Appeal 2007-2213
Application 10/355,433
(a) depositing drops, at least some of which contain
probe precursors, onto the substrate surface so that the probe
precursors bind to the surface through a linker, wherein all of
the drops containing probe precursors contain the same
concentration of probe precursors; and
(b) repeating (a) multiple times wherein the probe
precursor deposited in a prior cycle becomes the linker for a
probe precursor deposited in a subsequent cycle, so as to form
the array;
wherein the deposited drops comprise an unblocked-
hydroxy free and unblocked-amino free polymer to enhance
viscosity, and wherein the viscosities of the different drops
containing different probe precursors at the same concentration
are all within 4 cps of one another.
Claims 1 and 42 each recite that “all of the drops containing probe
precursors contain the same concentration of probe precursors.” The
Specification defines the term “same concentration” as concentrations that
are, “on a molar basis, . . . within 20% of one another” (Specification 10).
Thus, we interpret claims 1 and 42 to require that all of the drops containing
probe precursors contain concentrations of probe precursors that are, “on a
molar basis, . . . within 20% of one another.”
2. PRIOR ART
The Examiner relies on the following references:
Brennan US 5,474,796 Dec. 12, 1995
Okamoto US 6,476,215 B1 Nov. 5, 2002
Eckstein, F. ed., Oligonucleotides and Analogs, A Practical Approach.
(1991), p. 11.
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