Ex Parte Leproust et al - Page 8

                Appeal  2007-2213                                                                                  
                Application  10/355,433                                                                            

                       different probe precursors, wherein the viscosity of the drops                              
                       containing the different probe precursors varies by 2 cps or less                           
                       from one another.                                                                           
                (Id. at 12.)                                                                                       
                       We are not persuaded by these arguments.  As discussed above,                               
                Okamoto describes a viscosity of 1-15 cps (Okamoto, col. 4, ll. 43-45).                            
                Based on this teaching, we agree with the Examiner that a viscosity between                        
                7 and 15 cps would have been obvious, meeting the limitation in claim 1 of a                       
                viscosity “above 7 cps.”  Overlapping ranges support a prima facie case of                         
                obviousness.  See In re Geisler, 116 F.3d 1465, 1469, 43 USPQ2d 1362,                              
                1365 (Fed. Cir. 1997).                                                                             
                       Although Okamoto describes ranges of concentration and viscosity, it                        
                does not indicate that different drops should have different concentrations                        
                and viscosities within these ranges.  As also discussed above, we conclude                         
                that it would have been obvious to vary, as needed, the amount of viscosity                        
                enhancer in drops containing different phosphoramidites so that all of the                         
                drops have approximately the same viscosity (e.g., a viscosity within 2 cps                        
                of one another) so that the solutions would display the same properties in                         
                ejection from a pump and retention on a substrate.                                                 
                       Appellants also argue that “the Examiner’s assertion that different                         
                monomers prepared in the same solution inherently have the same viscosity                          
                is wrong” (Reply Br. 3).  Appellants point to the Table on page 4 of the                           
                Specification as showing that “the presence of the different                                       
                phosphoramidites changes the viscosity of the overall solution to a different                      
                extent” (id.).                                                                                     



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