Ex Parte Leproust et al - Page 11

                Appeal  2007-2213                                                                                  
                Application  10/355,433                                                                            

                same use.”).  In addition, we agree with the Examiner that the disclosure in                       
                Okamoto of a viscosity of from 1-15 cps provides a reasonable expectation                          
                of success over this range, including at a viscosity between 7 and 15 cps.                         
                       We conclude that the Examiner has set forth a prima facie case that                         
                claim 1 would have been obvious over Brennan and Eckstein in view of                               
                Okamoto, which Appellants have not rebutted.  We therefore affirm the                              
                rejection of claim 1 under 35 U.S.C. § 103.  Claims 2-4, 9-18, and 21-25 fall                      
                with claim 1.                                                                                      
                       Claim 5 indirectly depends from claim 1 and requires that, when only                        
                the viscosity enhancer is absent from the drops, they have a viscosity below                       
                9 cps.  Appellants argue that “nowhere does Brennan, Eckstein or Okamoto,                          
                alone or in combination, teach or suggest that when the viscosity enhancer is                      
                absent the viscosity of the probe precursor containing drops is below 9 cps”                       
                (Br. 15).                                                                                          
                       We are not persuaded by this argument.  Okamoto describes solutions                         
                containing a viscosity enhancer (e.g., ethylene glycol) and having a viscosity                     
                of 1-15 cps.  Because Okamoto teaches solutions containing a viscosity                             
                enhancer that can still have a viscosity below 9 cps, we agree with the                            
                Examiner that the cited references would have made obvious solutions that                          
                have a viscosity of less than 9 cps when the viscosity enhancer is absent.                         
                       Claim 7 depends from claim 5 and requires that “sufficient polymer is                       
                present to raise the viscosity of the drops comprising probe precursors by at                      
                least 2 cps.”  Appellants argue that “nowhere does Brennan, Eckstein or                            
                Okamoto, alone or in combination, teach or suggest that sufficient polymer                         
                is present to raise the viscosity of the drops comprising probe precursors by                      


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