Ex parte CHARLTON et al. - Page 3




          Appeal No. 94-2504                                                           
          Application 07/963,676                                                       
          of an injury to cells in mammalian tissue in vivo and                        
          treatment of epilepsy,” not “to compounds” as the examiner                   
          indicated.  Moreover, as filed, Claims 2-16 were all dependent               
          upon Claim 1 which generically defined the treating agent as                 
          “a cell membrane permeant calcium buffer.”  Needless to say,                 
          our attempts to comprehend the examiner’s restriction                        
          requirement have been unsuccessful.                                          
               In response to the restriction requirement (Paper No. 4,                
          filed January 6, 1993), applicants interpreted the examiner’s                
          restriction requirement as requiring restriction between                     
          (I) method Claims 1-16, (II) method Claims 23-25, (III)                      
          compound Claims 17-21, and (IV) composition Claim 22, and an                 
          election of a species of buffer.  Accordingly, applicants                    
          elected the method of Claim 10 and BAPTA-AM as the species of                
          buffer.                                                                      
               In a second office action mailed February 5, 1993 (Paper                
          No. 6), the examiner withdrew Claims 2-9 and 17-25 from                      
          consideration without explanation and indicated that Claims 1                
          and 10-16 would be examined.  The examiner then summarily                    
          rejected Claims 1 and 10-16 as follows (Paper No. 6, p. 2):                  
                    Claims 1 and 10-16 are rejected under 35 U.S.C. §                  
          112,                                                                         
               second paragraph, as being indefinite for failing to                    
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