Ex parte CHARLTON et al. - Page 6




          Appeal No. 94-2504                                                           
          Application 07/963,676                                                       
          Daniel Alkon (Alkon) and George J. Augustine (Augustine) to                  
          support their view that the claim defines “a well-defined                    
          class of materials to those in the art and, with the                         
          disclosure given . . . the invention could be practised [sic]                
          without difficulty using any such material as defined” (Alkon,               
          p. 3, para. 6; Augustine, p. 3, para. 6).                                    
               In the Examiner’s Answer (Ans., pp. 3-4), the examiner                  
          explained what he had meant by “broader than the specific                    
          supporting disclosure” in the first and FINAL office actions:                
               The claims do not structurally define the compounds to be               
               used and the K  range, a common property of structurally                
                             D                                                         
               diverse compounds, does not distinguish one potential                   
          drug                                                                         
               class from another.  Thus, one skilled in the art would                 
               have to imagine which drug to use.                                      
                    . . . . .                                                          
                    In this case, the compounds are not defined because                
               cell membrane permeant calcium buffer does not evoke a                  
               mental image of a chemical structure and the K  range is                
                                                              D                        
               such a general property that it does not distinguish a                  
               particular class of compounds.                                          
          The examiner added (Ans., pp. 4-5, bridging para.; emphasis in               
          original):                                                                   
                     In addition, claims to treating injury to cells                   
               in a host are not enabled because they are overly broad.                
               Treating injury to cells in a host reads on treating all                
               patients since normal physiology and all diseases result                
               in cell injury.  Applicant merely showing effect for cell               
               injury caused by select conditions, ischemia and                        
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