Ex parte CHARLTON et al. - Page 7




          Appeal No. 94-2504                                                           
          Application 07/963,676                                                       
          epilepsy.                                                                    
               Applicant does not provide a general teaching that the                  
               results shown would enable one skilled in the art to                    
          treat                                                                        
               all other diseases.  The pharmaceutical arts are                        
          inherently                                                                   
               unpredictable and method of universal treatment is highly               
               speculative as no single medical method is known which                  
          can                                                                          
               treat all diseases.  As such, the limited nature of the                 
               examples and [sic] are not sufficient quid pro quo for                  
               the broad claims in an unpredictable art to an invention                
               speculative in nature.  Ex parte Forman 230 USPQ 546                    
               (PTOB 1986).                                                            
               In a Reply Brief filed January 5, 1994, appellants argued               
          that the Examiner’s Answer had raised new arguments.  In                     
          response to the new arguments, appellants filed an Amendment                 
          Accompanying Reply Brief (Paper No. 14) which limited the                    
          claimed method to one for “reducing the damaging effect of an                
          excitotoxic, ischemic or traumatic injury” (Amendment, p. 1).                
          The examiner entered appellants’ Reply Brief and notified                    
          appellants of that action.    The examiner did not                           
          substantively respond to the extensive arguments set forth in                
          the Reply Brief.  See Paper No. 16. However, the examiner                    
          refused entry of the accompanying amendment.  See the                        
          handwritten instructions on Paper No. 14.  It does not appear                
          from the record the examiner informed appellants that the                    
          amendment was not entered.                                                   

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