Ex parte MORIMOTO et al. - Page 8




          Appeal No. 1996-1080                                                        
          Application No. 07/869,111                                                  

          different protecting groups is lost here since all the                      
          variables are not fixed.  In re Dunn, 349 F.2d 433, 439, 146                
          USPQ 479, 483 (CCPA 1965).              The declarant fails to              
          set forth any reasoning for employing “larger scale” reactions              
          than those disclosed by Watanabe, which, for some unexplained               
          reason, produces far less yield than reported by Watanabe (see              
          Experiments 1, 2 and page 15 of the Brief).  As noted by the                
          examiner on page 5 of the Answer, the claims are also not                   
          limited to any reaction conditions or specific methylating                  
          agents while the showing in the Declaration is limited to a                 
          particular methylating agent and specific reaction conditions.              
          Therefore the Declaration evidence has not been shown to be                 
          reasonably predictive of or commensurate in scope with the                  
          claimed subject matter.  In re Boesch, 617 F.2d 272, 276, 205               
          USPQ 215, 219 (CCPA 1980).                                                  
               Finally, we note that it is not enough that the results                
          for the claimed subject matter and the prior art invention are              
          different, as shown in Table 1 on page 5 of the Watanabe II                 
          Declaration.  Appellants must demonstrate that such results                 
          are unexpected.  In re Geisler, 116 F.3d 1465, 1469-70, 43                  
          USPQ2d 1362, 1365 (Fed. Cir. 1997); In re Merck & Co., Inc.,                

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