Appeal No. 1996-1080 Application No. 07/869,111 different protecting groups is lost here since all the variables are not fixed. In re Dunn, 349 F.2d 433, 439, 146 USPQ 479, 483 (CCPA 1965). The declarant fails to set forth any reasoning for employing “larger scale” reactions than those disclosed by Watanabe, which, for some unexplained reason, produces far less yield than reported by Watanabe (see Experiments 1, 2 and page 15 of the Brief). As noted by the examiner on page 5 of the Answer, the claims are also not limited to any reaction conditions or specific methylating agents while the showing in the Declaration is limited to a particular methylating agent and specific reaction conditions. Therefore the Declaration evidence has not been shown to be reasonably predictive of or commensurate in scope with the claimed subject matter. In re Boesch, 617 F.2d 272, 276, 205 USPQ 215, 219 (CCPA 1980). Finally, we note that it is not enough that the results for the claimed subject matter and the prior art invention are different, as shown in Table 1 on page 5 of the Watanabe II Declaration. Appellants must demonstrate that such results are unexpected. In re Geisler, 116 F.3d 1465, 1469-70, 43 USPQ2d 1362, 1365 (Fed. Cir. 1997); In re Merck & Co., Inc., 8Page: Previous 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 NextLast modified: November 3, 2007