Ex Parte TARGOFF et al - Page 3




              Appeal No. 1996-1281                                                                                     
              Application 07/945,295                                                                                   


              specification as relating to human antigens associated with certain autoimmune                           
              pathogenesis including inflammatory myopathies polymyositis and polymyositis-                            
              scleroderma overlap, which are characterized by chronic muscle inflammation and                          
              proximal muscle weakness in patients.  These antigens are designated Mi-2 antigen                        
              and PMScl antigen and are stated to be useful in diagnostic assays and as tools for                      
              studying autoimmune myositis.                                                                            
                                                     Discussion                                                        
                              The rejection under 35 U.S.C. § 112, second paragraph                                    
                     In a new ground of rejection raised in the Examiner's Answer (Answer), the                        
              examiner has rejected claims 11 - 15 and 26 stating (Answer, paragraph bridging pages                    
              6-7):                                                                                                    
                     [I]t is not clear if the claimed isolated protein is to have the sequence as                      
                     set forth in SEQ ID NO. 2 or can have that sequence as well as other                              
                     amino acid residue sequences so long as the isolated protein contains at                          
                     least one portion of the amino acid residue sequence of the human Mi-2                            
                     protein which has the amino acid residue sequence as set forth wherein                            
                     said "portion" includes at least one epitope.  The basis for this confusion                       
                     seems to stem for [sic, from] the varying uses of titles to identify the                          
                     protein and the antigen.                                                                          
              We have considered the arguments of both the examiner and the appellants relating to                     
              this rejection and find we are in agreement with the appellants that the rejection is                    
              improper.  We, therefore, reverse the rejection under 35 U.S.C. § 112, second                            
              paragraph, and adopt appellants' reasoning at page 3 of the Reply to Examiner's                          
              Answer as our own.                                                                                       
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