Ex Parte TARGOFF et al - Page 7



              Appeal No. 1996-1281                                                                                     
              Application 07/945,295                                                                                   


              undefined sequence, which includes at least one epitope, also of undefined sequence,                     
              which would result in the protein being immunoreactive with an autoantibody present in                   
              human sera where said antibody is immunoreactive with the protein having the amino                       
              acid sequence set forth in SEQ ID NO. 2.  It should be clear that the second                             
              interpretation results in a claim of broader scope.  A review of both the examiner's and                 
              appellants' position as presented in this appeal would suggest the importance of                         
              determining just what is encompassed by the claims.  We leave to the examiner and                        
              appellants the determination of the appropriate interpretations.  Only after it is                       
              determined what is encompassed by the claim, can one make the informed decision                          
              whether the bovine Mi-2 antigen described by Targoff is reasonably encompassed by                        
              the claim.                                                                                               
                     Having determined what is claimed, then the examiner is in the position to                        
              determine whether the proteins described by Targoff can reasonably be said to fall                       
              within the scope of claim 11.  The examiner bears the initial burden of presenting a                     
              prima facie case of obviousness.  In re Oetiker, 977 F.2d 1443, 1445, 24 USPQ2d                          
              1443, 1444 (Fed. Cir. 1992).  Only if that burden is met, does the burden of coming                      
              forward with evidence or argument shift to the applicant.  Id.  In reconsidering the                     
              patentability of the claims in this application we would urge the examiner to consider the               
              principles set forth in  In re Best, 562 F.2d 1252, 1254, 195 USPQ 430, 433 (CCPA                        
              1977) and In re Swinehart, 439 F.2d 210, 212, 169 USPQ 226, 228-29 (CCPA 1971)                           
              which provide that where the claimed and prior art products reasonably appear to be                      
              identical or substantially identical, the PTO can require an applicant to show that the                  

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