Ex Parte TARGOFF et al - Page 4




              Appeal No. 1996-1281                                                                                     
              Application 07/945,295                                                                                   


                                     The rejection under 35 U.S.C. § 102(b)/103                                        
                     In rejecting claims 11-13 under 35 U.S.C. § 102(b) or, alternatively, under 35                    
              U.S.C. § 103, the examiner relies on Targoff as teaching an isolated Mi-2 protein                        
              derived from calf thymus which binds to human autoantibodies, identified as "anti-Mi-2"                  
              antibodies, to human Mi-2 proteins.  The examiner's position appears to be that the                      
              protein of the reference is encompassed by claim 11 since it is described as being                       
              immunogenically reactive with a human anti-Mi-2 antibody.  The examiner concludes                        
              that this protein must inherently include at least one epitope as required by claim 11,                  
              and, thus, must inherently include at least a portion of the amino acid sequence of the                  
              SEQ ID NO. 2. (Answer, page 5).   In explaining the obviousness aspect of the                            
              rejection, the examiner merely argues that it would have been obvious to have used the                   
              human autoantibodies which are immunoreactive with the Mi-2 antigen, as taught by                        
              Targoff, to isolate the protein which contains at least one epitope of human Mi-2                        
              antigen. (Answer, page 6).                                                                               
                     We have reviewed both the examiner's rejection and appellants' rebuttal                           
              arguments and evidence.  However, on this record we do not find that the issues, as                      
              presented, permit a meaningful review.  In arguing their respective positions on the                     
              issues raised by the rejection of claims 11-13 over Targoff, it does not appear that                     
              either the examiner or appellants have considered the most relevant legal standard                       
              appropriate for consideration of the facts presented in this appeal.  Additionally, we note              

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