Appeal No. 1997-1987
Application No. 08/108,005
complications. This is manifested by demyelination, in the
form
of multifocal progressive leukoencephalopathy. Symptoms range
from slight psychic disturbance to a clear neurological
syndrome. Approximately ten percent of AIDS patients show
serious neurological symptoms (aphasia, ataxia, areflexia,
including paralysis and loss of sphincteric control); and in
sixty-two percent of HIV-positive subjects, organic mental
disturbances are described leading to alteration of the
cognitive functions and to dementia. Specification, page 1,
line 14, to page 2, line 3. The literature has reported that
HIV-positive patients with accompanying neurological
complications can exhibit deficiencies in 5-methyl-
tetrahydrofolate (MTHF) and S-adenosylmethionine (SAMe).
Specification, page 2, lines 3-5. Data from the literature
suggest that deficiencies in MTHF and SAMe can be the cause of
neurological degeneration in AIDS patients. Specifica-tion,
page 2, line 16, to page 3, line 3. Administration of
methionine and betaine has been suggested to correct these
metabolic deficiencies. R. Surtees et al., The Lancet, vol.
2
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