Ex Parte EVANS et al - Page 13


                 Appeal No.  2001-2584                                                        Page 13                  
                 Application No.  08/462,817                                                                           
                        Upon consideration of co-pending Application No. 08/464,574 (Appeal No.                        
                 2001-1582) we find two rejections that may be applicable to the present claims.                       
                 For clarity we reproduce claims 47 and 51 of co-pending application 08/464,574                        
                 below:                                                                                                
                               47. Isolated DNA encoding a member of the steroid/thyroid                               
                                    hormone receptor superfamily, wherein said member has an                           
                                    N-terminal domain, a DNA binding domain and a ligand                               
                                    binding domain, and wherein said DNA binding domain is a                           
                                    cysteine-rich domain comprising 66 amino acid residues.                            
                               51. An expression vector containing DNA according to claim 47.                          
                        In co-pending Application No. 08/464,574 the examiner found claim 51 to                        
                 have been obvious over the combination of Walter in view of Leonard.                                  
                 According to the examiner in that application, Walter teach, inter alia, a human                      
                 estrogen receptor, and Leonard teach, inter alia, an expression vector and host                       
                 cell.  See 08/464,574, Answer, pages 8-10.  It appears that this rejection is                         
                 applicable to the claims on appeal in this application.                                               
                        Furthermore, in co-pending application 08/464,574 the examiner rejected                        
                 all the claims under the judicially created doctrine of obviousness-type double                       
                 patenting over claims 1-23 of U.S. Patent No. 5,312,732.  Claims 1 and 17 of                          
                 U.S. Patent No. 5,312,732 read as follows:                                                            
                        1.        Recombinant DNA capable of hybridizing with DNA encoding                             
                                  protein having the amino acid sequence shown in FIG. IV-2(B)                         
                                  (hMR), FIG. V-1(B) (hERR1), or FIG. V-2(B) (hERR2), or DNA                           
                                  complementary thereto, under low stringency hybridization                            
                                  conditions, wherein said DNA encodes functional receptor                             
                                  protein(s) having hormone-binding and/or transcription                               
                                  activating properties of mineralocorticoid receptor, estrogen-                       
                                  related receptor hERR1 or estrogen-related receptor hERR2.                           







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