Appeal No. 2001-1335
Application No. 08/843,582
antimalarially effective amount of at least one compound selected
from a group of particular arylisoquinoline compounds or
derivatives thereof. The appealed subject matter also relates to
a method of treating or preventing a malarial infection or of
inhibiting the growth of a malarial parasite which comprises
administering an antimalarially effective amount of at least one
compound selected from the aforementioned group. This appealed
subject matter is adequately illustrated by independent claims 28
and 34, a copy of which taken from the appellants’ brief is
appended to this decision.
The references relied on by the examiner in the section 102
and section 103 rejections before us are set forth below:
Sloan 5,001,115 Mar. 19, 1991
Bringmann et al. (Bringmann III) 5,260,315 Nov. 9, 1993
Ruangrungsi et al. (Ruangrungsi), “Traditional medicinal plants
of Thailand, V. Ancistrotectorine, a new naphthaleneisoquinoline
alkaloid from ancistrocladus tectorius,” Journal of Natural
Products, vol. 48, No. 4, pp. 529-535 (1985).
Bundgaard, “Design of prodrugs: Bioreversible derivatives for
various functional groups and chemical entities,” Design of
Prodrugs, pp. 1-3, 10, 35-37 (1985).
Bringmann et al. (Bringmann V), “On the structure of the
dioncophyllaceae alkaloids dioncophylline A (“triphyophylline”)
and ‘O-methyl-triphyophylline’,” Tetrahedron Letters, Vol. 31,
No. 5, pp. 639-642 (1990).
Bringmann et al. (Bringmann II), “Atrop-diastereomer separation
by racemate resolution techniques: N-methyl-dioncophylline A and
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