Ex Parte FRANCOIS et al - Page 4




          Appeal No. 2001-1335                                                        
          Application No. 08/843,582                                                  

               Regarding the section 102 rejection of composition claim 28,           
          the examiner states that “the instantly claimed composition is              
          anticipated by Bringmann’s aqueous formulation comprising 0.05%             
          dioncophylline B and water (column 4, lines 10-13), which is also           
          a pharmaceutically acceptable carrier” (answer, page 4).  We                
          cannot agree for at least two reasons.  First, it is not at all             
          clear that Bringmann’s aqueous formulation (i.e., the formulation           
          of patentee’s Example 1) constitutes a pharmaceutical composition           
          of at least one pharmaceutically acceptable carrier as required             
          by the claim under review.  This is because, contrary to the                
          examiner’s apparent belief, this formulation does not comprise              
          only dioncophylline B and water.  It also includes at least one             
          other ingredient, namely, an emulsifier (e.g., see line 56 in               
          column 3).  For all we know, this additional ingredient may be              
          contrary to a pharmaceutical composition having at least one                
          pharmaceutically acceptable carrier as required by the here                 
          rejected claim.  Thus, the examiner necessarily has implicitly              
          assumed that Bringmann’s formulation comprises the appellant’s              
          claimed pharmaceutical composition having at least one                      
          pharmaceutically acceptable carrier.                                        
               Additionally, the examiner necessarily has implicitly                  
          assumed that Bringmann’s formulation satisfies the antimalarially           

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