Appeal No. 2001-1335
Application No. 08/843,582
APPENDIX
28. A pharmaceutical composition consisting essentially of
at least one pharmaceutically acceptable carrier and an
antimalarially effective amount of at least one compound selected
from the group consisting of dioncophylline B, dioncopeltine A,
dioncophylline A, dioncophylline C, ancistrobrevine D,
ancistrocladine, N-methyl-dioncophylline A and the atropisomer
thereof, dioncophylleine A, (+) - dioncophyllacine A, hamatine,
ancistrobrevine B, ancistrobrevine A, 6-O-demethyl-
ancistrobrevine A, ancistrobarterine A, 7-epi-dioncophylline A,
N-formyl-ancistrocladine, N-methyl-ancistrocladine, 6-deoxy-N-
methyl-ancistrocladine, N-formyl-O,O-dimethyl-dioncophylline C,
N-formyl-dioncophylline C, N-formyl-8-O-benzyl-dioncophylline C,
N-formyl-8-O-methyl-dioncophylline C, N-formyl-8-O-pivaloyl-
dioncophylline C, N-formyl-8-O-acetyl-dioncophylline C, N-formyl-
8-O-benzoyl-dioncophylline C, and 8-O-methyl-dioncophylline C,
and pharmacologically acceptable salts thereof, optionally in
combination with an antimalarially effective amount of at least
one additional antimalarial compound selected from the group
consisting of chloroquine, mefloquine, halofantrine, artemisinin,
artemether, pyrimethamine, and quinine.
34. A method of treating or preventing a malarial infection
which comprises administering to a mammal in need thereof an
antimalarially effective amount of at least one compound selected
from the group consisting of dioncophylline B, dioncopeltine A,
dioncophylline A, dioncophylline C, ancistrobrevine D,
ancistrocladine, N-methyl-dioncophylline A and atropisomer
thereof, dioncophylleine A, (+) - dioncophyllacine A, hamatine,
ancistrobrevine B, ancistrobrevine A, 6-O-demethyl-
ancistrobrevine A, ancistrobarterine A, 7-epi-dioncophylline A,
N-formyl-ancistrocladine, N-methyl-ancistrocladine, 6-deoxy-N-
methyl-ancistrocladine, N-formyl-O,O-dimethyl-dioncophylline C,
N-formyl-dioncophylline C, N-formyl-8-O-benzyl-dioncophylline C,
N-formyl-8-O-methyl-dioncophylline C, N-formyl-8-O-pivaloyl-
dioncophylline C, N-formyl-8-O-acetyl-dioncophylline C, N-formyl-
8-O-benzoyl-dioncophylline C, and 8-O-methyl-dioncophylline C,
and pharmacologically acceptable salts thereof.
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