Ex Parte FRANCOIS et al - Page 5




          Appeal No. 2001-1335                                                        
          Application No. 08/843,582                                                  

          effective amount limitation of appealed claim 28.  In this                  
          regard, the examiner urges that “the 0.05% of dioncophylline B in           
          the aqueous formulation (column 4, lines 10-13) would fall within           
          the effective range of the instant antimalarial composition for a           
          dosage of 0.01 mg/kg body weight to 100 mg/kg body weight (page             
          32 of the specification)” (answer, page 8).  However, there is              
          absolutely no basis for the examiner’s belief that patentee’s               
          disclosure of 0.05% dioncophylline B would fall within the range            
          of antimalarially effective amounts disclosed by the appellants             
          on page 32 of their specification.  In fact, it is clear that               
          Bringmann’s 0.05% value relates to the concentration of                     
          dioncophylline B in his formulation and not to the total amount             
          of the dioncophylline B present in the formulation.  It is this             
          total amount which must be known in order to assess whether it              
          corresponds to the amounts disclosed by appellants as being                 
          antimalarially effective.  Our study of Bringmann’s Example 1               
          disclosure reveals that it is impossible to know the total amount           
          of dioncophylline B which was present in the Example 1                      
          formulation.                                                                
               In light of the foregoing, it is apparent that the                     
          examiner’s anticipation position is based on assumption and                 
          conjecture.  It is well settled that anticipation under section             

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