Interference 103,781
this solution to improve codon, preferred codons and codon
frequency in genes.
Here, Dr. Adang refers to his chats with Dr. Murray regarding the
solution to improve the number and frequency of plant-preferred
codons in Bt gene sequences. The best Dr. Adang could do in the
District Court of Southern California was cite the same
documentary evidence he previously cited, i.e., Dr. Murray’s lab
notebook and the draft abstract for his UCLA talk (AX 101B;
AX 106E), and prior knowledge in the art. For example, in
California, when asked if there was anything which helped him to
date his conversations with Dr. Murray, Dr. Adang testified
(AR 0092, l. 6, -0093, l. 2; emphasis added):
[W]hat has helped me some in terms of focusing in on the
date of that time was [sic] – an understanding of when,
about when Liz’s northern blot results were obtained.
My recollection of searching the Bt gene for various
sequences that I thought, perhaps, might be deleterious
to expression. And so there’s sort of these events of
data we were seeing, my recalling doing various computer
searches. And then knowing, you know, my interaction
with Liz and remembering sort of these discussions at
that period. So it kind of fits in with, I think, very
well with that late 1985 period of time.
Q. When the idea was conceived, either by you or by
Elizabeth Murray, of increasing the number of preferred
codons in the native Bt gene to improve expression, did
you or she write the idea down?
. . . . .
THE WITNESS: I don’t recall.
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