Interference 103,781
Dr. Adang’s California testimony continued (AR 0094,
l. 8, - AR 0095, l. 22):
. . . I saw evidence of my steps towards modifying Bt
genes for improved usage and frequency as well as number
of preferred-plant codons.
Q. And what evidence did you see?
A. . . . I saw data on codon usage, analysis of plant
genes. I saw analyses of Bt codons and Bt gene codon
usage. And I also recall seeing analyses of - that led
to design and synthesis of synthetic Bt gene, designs
along those principles of codon preference and codon
usage.
Q. When did work on codon usage tables begin?
. . . . .
THE WITNESS: Well, it depends what one means on work on
codon usage tables. You know, in the - I was aware of
codon usage tables in the literature, and you know, in
my own work, as a plant molecular biologist in the early
1980s. And so aware of these published literature values
on plant codon usage.
And later Liz began, along with her colleagues, the
actual construction of the codon usage tables, examples
that are presented in the patents.
Q. Do you know why Elizabeth Murray began construction
of her own codon usage tables rather than simply relying
on the codon usage tables in the published literature?
A. . . . My sort of - kind of my speculation on it, kind
of my recollection, would be that Liz wanted a more
complete representation of plant genes that were available
in deposited sequences in the nucleotide sequence databases
at the time. She just wanted a better survey of genes to
incorporate into her tables.
Specifically relating to the need for a more complete codon
usage table to enable persons skilled in the art to use the
-103-
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