Interference 103,781
concept of increasing the number of plant-preferred codons in the
native Bt gene in order to improve expression, Dr. Adang
testified (AR 0096, l. 21, - AR 0097, l. 2; emphasis added):
[M]y opinion . . . is that we could have taken the codon
usage tables available at the time. It perhaps would
have been riskier than what we actually did in terms of
trying to - not trying to, but compiling broader tables.
Asked when Elizabeth Murray began work to construct her own
codon usage tables (AR 0098, l. 9-10), Dr. Adang testified
(AR 0098, l. 12-22)(emphasis added):
When Liz - it’s difficult for me to say the exact time
when Liz started to construct her own codon usage tables.
You know, my recollection of that, ‘86 - my recollection is
that it was in ‘86 when she came to me and we discussed
assembling of plant codon usage tables.
But she perhaps had been doing that before, you know,
on her own. Then she came to me with this idea of bringing
it into sort of a broader part of the project and getting
some assistance with it.
Immediately thereafter, Dr. Adang testified regarding the
relationship of codon usage tables to the invention claimed in
Adang’s involved patent (AR 0104, l. 25, - AR 0105, l. 11):
Q. You mentioned in an earlier answer, about the
same breadth as codon usage tables, an analysis of plant
genes. And I wanted to ask you, was the analysis of plant
genes something different from the codon usage tables?
A. An analysis of plant genes would include but not
be limited to codon usage.
Dr. Adang provided the following additional testimony
(AR 0107, l. 19, - AR 0108, l. 0111, l. 5)(emphasis added):
-104-
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