Interference 103,781
Q. As a result of looking at codon usage tables
published for plant genes and comparing those to your codon
usage table for the Bt gene, did you draw any conclusion?
A. We concluded that the Bt genes had different codon
usage and different preferred codons than plant genes.
. . . . .
Q. So the “we” is you and Elizabeth Murray?
A. Yes, that’s correct.
Q. . . . Did you identify specific codons in the
native Bt gene that occurred more frequently than in plants?
A. In looking at the native Bt genes, a feature that
was striking to me was the number of codons ending in As
or Ts at the wobble base position.
Q. Why is that striking?
A. Well, it was striking because that’s in opposition
to or quite contrast to plant gene. You know, plant genes
are rich in Gs and Cs at the third nucleotide position.
Q. Do you recall drawing any other conclusions as a
result of the comparison you made between your codon usage
table for the native Bt gene and the published data
involving codon usage in plants?
A. Well, I recall that we took the step of saying
Bt genes should be made to look more plant-like by building
to include codons preferred and match the usage of plant
codons.
Thereafter, when asked about the first time after November of
1985 that Liz Murray, or anyone else, communicated to him a
comparison of codon frequencies for Bt genes and codon
frequencies for plants (AR 0128, l. 10-13), Dr. Adang testified
(AR 0128, l. 14-18):
-110-
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