Appeal No. 2006-2710
Application No. 10/458,114
We conclude that the Examiner has set forth a prima facie case of
obviousness. Neumann describes a stationary phase for chromatography
that is modified to include a large number of functional groups. “The goal is
achieved by modifying the stationary phase by means of chemically bound
dendrimers or dendrones.” (Neumann 1-2.) As the stationary phase,
Neumann describes silica gels. (Id.)
Neumann states that the preferred dendrimers are poly(melamine)-
dendrimers. (Id. at 3.) In addition, Neumann discloses that “the dendrimers
or dendrones are functionalized by appropriate groups, in particular . . .
NR2R3, where . . . R2 [sic, R2] and R3, which may be identical or different,
denote H, [or] optionally substituted alkyl having 1-20 C atoms. . . .” (Id. at
3-4.) Thus, we conclude that the Examiner has set forth a prima facie case
that Neumann describes alkylated amine dendritic materials that are
chemically bound to a solid substrate.
Snyder describes preparing chromatography packings by attaching a
bonded phase to a siliceous support via surface silanol groups. (Snyder
272.) Snyder teaches that “the most useful and most widely available BPC
[bonded phase chromatography] packings are those based on siloxanes,”
which are typically “prepared by reacting the silanol groups of the support
with organochlorosilane or organoalkoxysilane reagents (depending on the R
group desired),” and that “[b]onded phases of this type are hydrolytically
stable.” (Snyder 273. See also, Snyder Fig. 7.1(c).) Thus, Snyder describes
using an organosilane compound as the means for attaching an organic
group to a silica support. Based on this teaching, we conclude that the
Examiner has set forth a prima facie case that, in order to form the highly
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