Ex Parte Skinner et al - Page 6

               Appeal No. 2006-2710                                                                        
               Application No. 10/458,114                                                                  

               functionalized stationary phase described in Neumann, it would have been                    
               obvious to use a silane bonding agent as the means for attaching a dendrimer                
               to a silica support.                                                                        
                      Appellants argue that “Neumann binds polymers using organic                          
               binding agents, namely, triazine, which is a trifunctional molecule wherein                 
               all of the nitrogen atoms are functional and active.  This fact in itself dictates          
               that the Neumann materials are different and do not make the materials of                   
               the instant invention obvious.”  (Br. 3.)  Appellants also argue that “the                  
               processes as taught in Snyder do not . . . teach binding dendritic materials to             
               solid substrates.”  (Br. 4.)                                                                
                      We do not find these arguments persuasive.  The Examiner is not                      
               relying on either Neumann or Snyder to individually teach or suggest all of                 
               the features of claim 1.  Instead, the Examiner is arguing that the                         
               combination of these two references renders claim 1 obvious.  We conclude                   
               that the Appellants have not overcome the Examiner’s prima facie case that                  
               the combination of Neumann with Snyder renders claim 1 obvious.                             
                      Appellants argue that “Neumann necessarily needs to modify the solid                 
               substrate so that the triazine can be used therein, by treating the substrate               
               with an amino compound.  This leads to materials that are created by at least               
               a two step process just to create the amino functional polymer, and the                     
               resulting materials are crosslinked, whereas the materials of the instant                   
               invention are not.”  (Br. 3.)  In addition, Appellants argue that “Neumann                  
               treats the solid substrate with his bonding agents, and then builds the                     
               dendritic polymer onto that surface, while the process of the instant                       
               invention merely bonds already formed bulky dendrimers to solid substrates                  


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